SCCS Issued Preliminary Opinion on Benzophenone-1

On November 7, 2024, the Scientific Committee on Consumer Safety (SCCS) of the European Union issued a preliminary opinion on Benzophenone -1 (CAS No. 131-56-6). The deadline for comments on SCCS/1672/24 is set for January 13, 2025.

The SCCS concludes the following:

Having considered the data provided, and the concerns relating to the potential endocrine disrupting properties of Benzophenone-1 (BP-1), the SCCS cannot conclude on the safety of BP-1, because the information provided is insufficient to exclude genotoxicity.

The available evidence also shows that BP-1 is an endocrine-active substance due to clear demonstration of estrogenic activity and weak anti-androgenic activity both in vitro and in vivo, and potential activity against thyroid modality in vitro.

The Chinese Cosmetic Ingredient Regulatory Database ( ChinaCosIng ), independently developed by CIRS Group, indicates that Benzophenone -1, used as light stabilizer and UV absorber, has been included in the "Inventory of Existing Cosmetic Ingredients in China" (IECIC) (2021 edition) with the maximum historical usage in leave-on products being 0.936%.

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Further Information

Collection of SCCS's Opinion on Cosmetic Ingredients